Cassandra M J WannanBarnaby NelsonJean AddingtonKelly AllottAlan AnticevicCelso ArangoJustin T BakerCarrie E BeardenTashrif BillahSylvain BouixMatthew R BroomeKate BuccilliKristin S CadenheadMonica E CalkinsTyrone D CannonGuillermo CecciEric Yu Hai ChenKang Ik K ChoJimmy ChoiScott R ClarkMichael J ColemanPhilippe ConusCheryl M CorcoranBarbara A CornblattCovadonga M Diaz-CanejaDominic DwyerBjørn H EbdrupLauren M EllmanPaolo Fusar-PoliLiliana GalindoPablo A GasparCarla GerberLouise Birkedal GlenthøjRobert GlynnMichael P HarmsLeslie E HortonRené S KahnJoseph KambeitzLana Kambeitz-IlankovicJohn M KaneTina KapurMatcheri S KeshavanSung-Wan KimNikolaos KoutsoulerisMarek KubickiJun Soo KwonKerstin LangbeinKathryn E LewandowskiGregory A LightDaniel MamahPatricia J MarcyDaniel H MathalonPatrick D McGorryVijay A MittalMerete NordentoftAngela NunezOfer PasternakGodfrey D PearlsonJesus PerezDiana O PerkinsAlbert R PowersDavid R RoalfFred W SabbJason SchiffmanJai L ShahStefan SmesnyJessica SparkWilliam S StoneGregory P StraussZailyn TamayoJohn TorousRachel UpthegroveMark VangelSwapna VermaJijun WangInge Winter-van RossumDaniel H WolfPhillip WolffStephen J WoodAlison R YungCarla AgurtoMario Alvarez-JimenezPaul AmmingerMarco ArmandoAmeneh Asgari-TarghiJohn CahillRicardo E CarriónEduardo CastroSuheyla Cetin-KarayumakM Mallar ChakravartyYoungsun T ChoDavid CotterSimon D’AlfonsoMichaela EnnisShreyas FadnavisClara FonteneauCaroline GaoTina GuptaRaquel E GurRuben C GurHolly K HamiltonGil D HoftmanGrace R JacobsJohanna JarchoJie Lisa JiChristian G KohlerParis Alexandros LalousisSuzie LavoieMartin LepageEinat LiebenthalJosh MervisVishnu MurtySpero C NicholasLipeng NingNora PenzelRussell PoldrackPablo PoloseckiDanielle N PrattRachel RabinHabiballah Rahimi EichiYogesh RathiAvraham ReichenbergJenna ReinenJack RogersBernalyn Ruiz-YuIsabelle ScottJohanna Seitz-HollandVinod H SrihariAgrima SrivastavaAndrew ThompsonBruce I TuretskyBarbara C WalshThomas WhitfordJohanna T W WigmanBeier YaoHok Pan YuenUzair AhmedAndrew (Jin Soo) ByunYoonho ChungKim DoLarry HendricksKevin HuynhClark JeffriesErlend LaneCarsten LangholmEric LinValentina MantuaGennarina SantorelliKosha RuparelEirini ZoupouTatiana AdasmeLauren AddamoLaura AderyMunaza AliAndrea AutherSamantha AversaSeon-Hwa BaekKelly BatesAlyssa BatheryJohanna M M BayerRebecca BeedhamZarina BilgramiSonia BirchIlaria BonoldiOwen BordersRenato BorgattiLisa BrownAlejandro BrunaHolly CarringtonRolando I Castillo-PassiJustine ChenNicholas ChengAnn Ee ChingChloe CliffordBeau-Luke ColtonPamela ContrerasSebastián CorralStefano DamianiMonica DoneAndrés EstradéBrandon Asika EtukaMelanie FormicaRachel FurlanMia GeljicCarmela GermanoRuth GetachewMathias GoncalvesAnastasia HaidarJessica HartmannAnna JoOmar JohnSarah KerinsMelissa KerrIrena KesselringHoney KimNicholas KimKyle KinneyMarija KrcmarElana KotlerMelanie LafanechereClarice LeeJoshua LlerenaChristopher MarkiewiczPriya MatnejlAlejandro MaturanaAissata MavambuRocío Mayol-TroncosoAmelia McDonnellAlessia McGowanDanielle McLaughlinRebecca McIlhennyBrittany McQueenYohannes MebrahtuMartina MensiChristy Lai Ming HuiYi Nam SuenStephanie Ming Yin WongNeal MorrellMariam OmarAlice PartridgeChristina PhassouliotisAnna PichiecchioPierluigi PolitiChristian PorterUmberto ProvenzaniNicholas PrunierJasmine RajSusan RayVictoria RaynerManuel ReyesKate ReynoldsSage RushCesar SalinasJashmina ShettyCallum SnowballSophie TodGabriel Turra-FariñaDaniela ValleSimone VealeSarah WhitsonAlana WickhamSarah YounFrancisco ZamoranoElissa ZavagliaJamie ZinbergScott W WoodsMartha E Shenton2024-10-102024-10-102024https://investigadores.udd.cl/handle/123456789/1008310.1093/schbul/sbae011<jats:title>Abstract</jats:title> <jats:p>This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.</jats:p>journal-article