Here, we develop an historical quantitative approach integrating a novel chemostratigraphic record, data on policy making, and socio-economic trends to evaluate the feedback relationship between environmental injustice and Anthropocene in sacrifice zones. We specifically outlined a case study for the Puchuncavi valley -one of the most emblematic sacrifice zones from Chile-. We verify an ever-growing burden of heavy metals and metalloids over the past five decades paced by the staggering expansion of local industrial activities, which has ultimately been spurred by national and transnational market forces. Local poverty levels have declined concomitantly, but this path towards social equality is marginal as costs of pollution have exacerbated through time. Indeed, national and international pollution control actions appear insufficient in mitigating the cumulative impact brought by highly toxic elements. Thus, our sub-decadal reconstruction for pollution trends over the past 136 years from a sediment record, emerges as a science-based instrument for informing the discussion on Anthropocene governance. Furthermore, it helps to advance in the assessment of environmental inequality in societal models that prioritize economic growth to the detriment of socio-environmental security.

Data and scripts for moral tradeoff system paper in PNAS

We compiled criteria pollutants from four air quality monitoring stations in Bogotá, eight in Santiago, and five in São Paulo to characterize the impact of emission changes on air quality during the early Coronavirus-imposed lockdown. Time series include hourly measurements (UTC) of ozone (ppbv), nitric oxide (ppbv), nitrogen dioxide (ppbv), carbon monoxide (ppmv), and PM2.5 (microgram per cubic meter), from 1 January 2014 to 1 June 2020.

This dataset contains urban vehicle exhaust emission of NO2 and MP2.5 from on-road transportation in Santiago, Chile, for the period March-June 2020; and PM10 exhaust emissions at Bogota, Colombia, for March-April 2020. The data is presented as NetCDF4 files, in Gg/y per cell for each specie and at different hours, gridded with a spatial resolution of 0.01° x 0.01°. Santiago includes three periods: 7, 12 and 19 hours, and Bogota comprises the periods: 5, 12 and 21 hours.

Clinically identified genetic variants in ion channels can be benign or cause disease by increasing or decreasing the protein function. Consequently, therapeutic decision-making is challenging without molecular testing of each variant. Our biophysical knowledge of ion channel structures and function is just emerging, and it is currently not well understood which amino acid residues cause disease when mutated. We sought to systematically identify biological properties associated with variant pathogenicity across all major voltage and ligand-gated ion channel families. We collected and curated 3,049 pathogenic variants from hundreds of neurodevelopmental and other disorders and 12,546 population variants for 30 ion channel or channel subunits for which a high-quality protein structure was available. Using a wide range of bioinformatics approaches, we computed 163 structural features and tested them for pathogenic variant enrichment. We developed a novel 3D spatial distance scoring approach that enables comparisons of pathogenic and population variant distribution across protein structures.

Couples’ extrinsic emotion regulation strategies are associated with marital quality or dyadic adjustment. However, only the strategies employed according to the objective they are expected to achieve have been examined; it is not known if strategies on the bases of positive or negative extrinsic emotion regulation motivation would have the same consequences for the dyad. The purpose of this study was to examine if extrinsic emotion regulation (EER) predicts one's own and one's partner's dyadic adjustment and if this effect differs by gender and relationship length. Using the Actor-Partner Interdependence Model (a type of dyadic data analysis, which incorporates the scores of the two members of the relationship into the analyses), data from 103 Chilean couples who completed self-report scales on dyadic adjustment and EER were analyzed. The participants were between 22 and 78 years old (Mmen = 39.84, SD = 11.37; Mwomen = 38.01, SD = 10.64), and the relationship lengths were between 1 and 50 years (M = 12.98, SD = 11.53). The motivation or the intention to make the partner feel good (positive) or bad (negative) respectively predict higher and lower dyadic adjustment in both the one who uses the strategy (actor) and the receiver of the strategy (partner). There was no difference by gender or by duration of the relationship in the dyads, but there was with children in common. It is important to consider the motivation underlying the emotional management of the couple, given its implication in marital quality and the need to broaden the understanding of other EERs related to healthy dyadic functioning.

Dataset for Pelgrim et al. (2021). Functional connectivity (FC) matrices were created by computing Pearson correlation coefficients between the mean time course of 105 regions of interest (ROIs) of the functional MRI images, then converted to normally distributed Z-scores using Fisher's r-to-Z-transformation. - 40 connectivity matrices of 22q11 deletion syndrome patients - 76 connectivity matrices of healthy controls - subject data - names of 105 ROIs

Neurodevelopmental disorders (NDDs) are a heterogeneous group of conditions involving various forms of disruption to brain development. Over hundreds of genes have been found to be associated with NDDs thus far. However, NDDs are complex and mutations in NDD associated genes are not straightforward to conceptualize at the molecular level, for which three-dimensional (3D) structures of proteins provide an informative mean. Here, we present the ES-NDD a tool that provides access to the aggregation of >470 experimentally and computationally modeled 3D monomeric structures as well as multimeric protein complexes and their characterization using a consensus approach to identity Essential3D sites are conserved across human paralogs. With ES-NDD a user is able to interactively explore 14, 377 Essential3D sites, that are paralog conserved, population constraint and enriched for pathogenic variants in the 3D structures, in the context of 71,479 population variants aggregated from gnomAD, 7,463 pathogenic (likely-pathogenic) variants from ClinVar and HGMD as well as functional and domain annotations from Uniprot.

Autism Spectrum Disorder (ASD) is a heterogeneous condition that affects face perception. Evidence shows that there are differences in face perception associated with the processing of low spatial frequency (LSF) and high spatial frequency (HSF) of visual stimuli between non-symptomatic relatives of individuals with autism (broader autism phenotype, BAP) and typically developing individuals. However, the neural mechanisms involved in these differences are not fully understood. Here we tested whether face-sensitive event related potentials could serve as neuronal markers of differential spatial frequency processing, and whether these potentials could differentiate non-symptomatic parents of children with autism (pASD) from parents of typically developing children (pTD). To this end, we performed electroencephalographic recordings of both groups of parents while they had to recognize emotions of face pictures composed of the same or different emotions (happiness or anger) presented in different spatial frequencies. We found no significant differences in the accuracy between groups but lower amplitude modulation in the Late Positive Potential activity in pASD. Source analysis showed a difference in the right posterior part of the superior temporal region that correlated with ASD symptomatology of the child. These results reveal differences in brain processing of recognition of facial emotion in BAP that could be a precursor of ASD.

This is the implementation of the 5 algorithms described in Vanhoof, M., Reis, F., Ploetz, T., & Smoreda, Z. (2018). Assessing the quality of home detection from mobile phone data for official statistics. In Journal of Official Statistics (Vol. 34, pp. 935–960). https://doi.org/10.2478/jos-2018-0046 that we used in our paper.